Neuroprotective Effects of Vitexin and Cajanus cajan Extract Against Pb-induced Neurotoxicity in Wistar Rats

Background: The effects of Pb-induced neurotoxicity have been largely established; however, the need for proper neuroprotective agents to mitigate remains vague. Objectives: This study aimed at investigating pre-treatment with vitexin and C. cajan extract against in Wistar rats. Methods: Twenty-four male rats were randomly assigned into four groups (n=6). control group was administered 0.5 mL distilled water, Pb received acetate (200 mg/kg), vitexin+Pb Vitexin (50 mg/kg) an hour before cajan+Pb mg/kg). All treatments done within 28 days. Barnes maze test novel object recognition (NOR) ascertain working memory, while levels oxidative stress markers (MDA, SOD, GPx) also tested. In addition, prefrontal cortical sections stained H&E stain, immunoreactivity Iba1 Nrf2 examined. Results: There a significant decline memory group, but good maintained pretreated groups. groups, stress, neuronal damage, expression significantly low compared group. Also, other Conclusion: Pretreatment offers neuroprotection toxicity via antioxidant anti-inflammation actions. Although both showed abilities, exhibited better results.